EC 184.108.40.206 - Russellysin
IntEnz Enzyme Nomenclature
Russell's viper blood coagulation factor X
Russell's viper venom factor X activator
blood-coagulation factor X-activating enzyme
- Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg bonds. Has no action on insulin B chain.
This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family).
Links to other databases
Coagulant protein of Russell's viper venom.Methods Enzymol. 45 : 191-205 (1976). [PMID: 1011991]
Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecent) and a protease from Russell's viper venom.J. Biol. Chem. 253 : 1902-1909 (1978). [PMID: 632245]
Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.J. Biol. Chem. 267 : 14109-14117 (1992). [PMID: 1629211]
[EC 220.127.116.11 created 1993]