EC - Russellysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Vipera russelli proteinase
Russell's viper blood coagulation factor X
Russell's viper venom factor X activator
blood-coagulation factor X-activating enzyme
metalloproteinase RVV-x
Systematic name:




This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 79393-92-3


  1. Furie, B.C. and Furie, B.
    Coagulant protein of Russell's viper venom.
    Methods Enzymol. 45 : 191-205 (1976). [PMID: 1011991]
  2. Lindquist, P.A., Fujikawa, K. and Davie, E.W.
    Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecent) and a protease from Russell's viper venom.
    J. Biol. Chem. 253 : 1902-1909 (1978). [PMID: 632245]
  3. Takeya, H., Nishida, S., Miyata, T., Kawada, S., Saisaka, Y., Morita, T. and Iwanaga, S.
    Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.
    J. Biol. Chem. 267 : 14109-14117 (1992). [PMID: 1629211]

[EC created 1993]