EC - Trimerelysin I

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IntEnz Enzyme Nomenclature


Accepted name:
trimerelysin I
Other names:
Trimeresurus metalloendopeptidase I
hemorrhagic metalloproteinase HR1A
hemorrhagic proteinase HR1A
metalloproteinase HR1A
Systematic name:




A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of the habu snake (Trimeresurus flavoviridis). In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 151125-16-5


  1. Omori-Satoh, T. and Sadahiro, S.
    Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts.
    Biochim. Biophys. Acta 580: 392-404 (1979). [PMID: 518906]
  2. Yamakawa, Y. and Omori-Satoh, T.
    The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis).
    Toxicon 26: 227-231 (1988). [PMID: 3284004]
  3. Takeya, H., Oda, K., Miyata, T., Omori-Satoh, T. and Iwanaga, S.
    The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis.
    J. Biol. Chem. 265: 16068-16073 (1990). [PMID: 2398046]

[EC created 1992]