EC 3.4.24.47 - Horrilysin

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IntEnz Enzyme Nomenclature
EC 3.4.24.47

Names

Accepted name:
horrilysin
Other names:
Crotalus horridus metalloendopeptidase
hemorrhagic proteinase IV
Systematic name:

Reaction

Cofactor

Comments:

A 56 kDa hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus) that cleaves basement membrane, hide powder and fibrinogen.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 84056-81-5

References

  1. Civello, D.J., Duong, H.L. and Geren, C.R.
    Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom.
    Biochemistry 22: 749-755 (1983). [PMID: 6340728]
  2. Civello, D.J., Moran, J.B. and Geren, C.R.
    Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom.
    Biochemistry 22: 755-762 (1983). [PMID: 6340729]

[EC 3.4.24.47 created 1992]