EC 3.4.24.46 - Adamalysin

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IntEnz Enzyme Nomenclature
EC 3.4.24.46

Names

Accepted name:
adamalysin
Other names:
Crotalus adamanteus metalloendopeptidase
Crotalus adamanteus venom proteinase II
adamalysin II
proteinase I and II
Systematic name:

Reaction

Cofactor

Comments:

From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 74812-51-4
UniProtKB/Swiss-Prot:

References

  1. Kurecki, T., Laskowski, M., Sr. and Kress, L.F.
    Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α 1-proteinase inhibitor.
    J. Biol. Chem. 253: 8340-8345 (1978). [PMID: 309470]

[EC 3.4.24.46 created 1992]