EC - Atrolysin E

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IntEnz Enzyme Nomenclature


Accepted name:
atrolysin E
Other name:
Crotalus atrox metalloendopeptidase e
Systematic name:




A 25.7 kDa hemorrhagic endopeptidase from the venom of the western diamondback rattlesnake (Crotalus atrox) that digests basement membrane components, including the triple helix of type IV collagen. Such action is believed to contribute to the hemorrhagic property by weakening capillary walls. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 172306-51-3


  1. Bjarnason, J.B. and Tu, A.T.
    Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e.
    Biochemistry 17: 3395-3404 (1978). [PMID: 210790]
  2. Bjarnason, J.B. and Fox, J.W.
    Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox).
    Biochemistry 22: 3770-3778 (1983). [PMID: 6351911]
  3. Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W.
    Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen.
    Matrix 10: 91-97 (1990). [PMID: 2374521]

[EC created 1992]