EC - Leishmanolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Leishmania metalloproteinase
glycoprotein gp63
promastigote surface endopeptidase
promastigote surface protease
surface acid proteinase
Systematic name:




A membrane-bound glycoprotein found on the promastigote of various species of Leishmania protozoans. Contains consensus sequence for a zinc-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The enzyme can activate its proenzyme by cleavage of the Val100┼Val bond. An acid pH optimum is found with certain protein substrates. Type example of peptidase family M8.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 161052-06-8


  1. Button, L.L. and McMaster, W.R.
    Molecular cloning of the major surface antigen of Leishmania.
    J. Exp. Med. 167 : 724-729 (1988). [PMID: 3346625]
  2. Bouvier, J., Cordier, C., Vogel, H., Reichelt, R. and Etges, R.
    Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase.
    Mol. Biochem. Parasitol. 37 : 235-246 (1989). [PMID: 2608099]
  3. Chaudhuri, G., Chaudhuri, M., Pan, A. and Chang, K.-P.
    Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages.
    J. Biol. Chem. 264 : 7483-7489 (1989).
  4. Bouvier, J., Schneider, P., Etges, R. and Bordier, C.
    Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania.
    Biochemistry 29 : 10113-10119 (1990). [PMID: 2271643]

[EC created 1992]