EC 3.4.24.35 - Gelatinase B

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IntEnz Enzyme Nomenclature
EC 3.4.24.35

Names

Accepted name:
gelatinase B
Other names:
92-kDa gelatinase
92-kDa type IV collagenase
95 kDa type IV collagenase/gelatinase
MMP 9
collagenase IV [ambiguous]
collagenase type IV [ambiguous]
gelatinase MMP 9
macrophage gelatinase
matrix metalloproteinase 9
type IV collagen metalloproteinase [ambiguous]
type V collagenase
Systematic name:
-

Reaction

Cofactors

Comments:

Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004229
CAS Registry Number: 146480-36-6
UniProtKB/Swiss-Prot:

References

  1. Hibbs, M.S., Hoidal, J.R. and Kang, A.H.
    Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.
    J. Clin. Invest. 80: 1644-1650 (1987).
  2. Wilhelm, S.M., Collier, I.E., Marmer, B.L., Eisen, A.Z., Grant, G.A. and Goldberg, G.I.
    SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
    J. Biol. Chem. 264: 17213-17221 (1989). [PMID: 2551898]
  3. Mainardi, C.L. and Hasty, K.A.
    Secretion and glycosylation of rabbit macrophage type V collagenase.
    Matrix 10: 84-90 (1990). [PMID: 2165210]

[EC 3.4.24.35 created 1992]