EC - Mycolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Streptomyces griseus neutral proteinase
actinase E
pronase component
Systematic name:




From Streptomyces griseus, S. naraensis, and S. cacaoi. Specificity similar to that of thermolysin, but much more sensitive to inhibition by mercaptoacetyl-Phe-Leu. Little structural similarity to other bacterial metalloendopeptidases. Type example of peptidase family M5. Formerly included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 153190-34-2


  1. Morihara, K., Tsuzuki, H. and Oka, T.
    Comparison of the specificities of various neutral proteinases from microorganisms.
    Arch. Biochem. Biophys. 123: 572-588 (1968). [PMID: 4967801]
  2. Hiramatsu, A. and Ouchi, T.
    A neutral proteinase from Streptomyces naraensis.
    J. Biochem. (Tokyo) 71: 767-781 (1972). [PMID: 5073323]
  3. Blumberg, S. and Tauber, Z.
    Inhibition of metalloendopeptidases by 2-mercaptoacetyl-dipeptides.
    Eur. J. Biochem. 136: 151-154 (1983). [PMID: 6413206]
  4. Chang, P.C., Kue, T-C., Tsugita, A. and Lee, Y.H.W.
    Extracellular metalloprotease gene of Streptomyces cacaoi: structure, nucleotide sequence and characterization of the cloned gene product.
    Gene 88: 87-95 (1990). [PMID: 2341042]

[EC created 1972 as EC, part transferred 1992 to EC]