EC - Coccolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Streptococcus thermophilus intracellular proteinase
EM 19000
Systematic name:




A 30 kDa endopeptidase found intracellularly in Streptococcus thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3, 4]. In peptidase family M4 (thermolysin family). Formerly included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 156859-08-4


  1. Desmazeaud, M.J.
    Propriétés générales et spécificité d'action d'une endopeptidase neutre intracellulaire de Streptococcus thermophilus.
    Biochimie (Paris) 56: 1173-1181 (1974). [PMID: 4451671]
  2. Desmazeaud, M.J. and Zevaco, C.
    General properties and substrate specificity of an intracellular neutral protease from Streptococcus diacetilactis.
    Ann. Biol. Anim. Biochem. Biophys. 16: 851-868 (1976).
  3. Smith, R.A.G., Green, J. and Kopper, P.H.
    The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis.
    Arch. Biochem. Biophys. 202: 629-638 (1980). [PMID: 6779709]
  4. Mäkinen, P.-L., Clewell, D.B., An, F. and Mäkinen, K.K.
    Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10).
    J. Biol. Chem. 264: 3325-3334 (1989). [PMID: 2536744]

[EC created 1972 as EC, part transferred 1992 to EC]