EC - Aureolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Staphylococcus aureus neutral protease
Staphylococcus aureus neutral proteinase
Systematic name:




A metalloenzyme from Staphylococcus aureus earlier confused with staphylokinase (a non-enzymatic activator of plasminogen). Formerly EC and included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 39335-13-2


  1. Arvidson, S.
    Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease.
    Biochim. Biophys. Acta 302: 149-157 (1973). [PMID: 4632563]
  2. Saheb, S.A.
    Purification et caractárisation d'une protáase extracellulaire de Staphylococcus aureus inhibáe par l'E.D.T.A.
    Biochimie 58: 793-804 (1976). [PMID: 823980]
  3. Drapeau, G.R.
    Role of a metalloprotease in activation of the precursor of staphylococcal protease.
    J. Bacteriol. 136: 607-613 (1978). [PMID: 711676]
  4. Potempa, J., Porwit-Bohr, Z. and Travis, J.
    Stabilization vs. degradation of Staphylococcus aureus metalloproteinase.
    Biochim. Biophys. Acta 993: 301-304 (1989). [PMID: 2512988]

[EC created 1972 as EC, part transferred 1992 to EC]