EC - Vibriolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Aeromonas proteolytica neutral proteinase
Systematic name:




Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 58500-42-8


  1. Holmquist, B. and Vallee, B.L.
    Esterase activity of zinc neutral proteases.
    Biochemistry 15: 101-107 (1976). [PMID: 2276]
  2. Wilkes, S.H. and Prescott, J.M.
    Aeromonas neutral protease.
    Methods Enzymol. 45: 404-415 (1976). [PMID: 1012006]
  3. Bayliss, M.E., Wilkes, S.H. and Prescott, J.M.
    Aeromonas neutral protease: specificity toward extended substrates.
    Arch. Biochem. Biophys. 204: 214-219 (1980). [PMID: 7000005]
  4. Wilkes, S.H., Bayliss, M.E. and Prescott, J.M.
    Critical ionizing groups in Aeromonas neutral protease.
    J. Biol. Chem. 263: 1821-1825 (1988). [PMID: 3123480]
  5. David, V.A., Deutch, A.H., Sloma, A., Pawlyk, D., Ally, A. and Durham, D.R.
    Cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of Vibrio proteolyticus.
    Gene 112: 107-112 (1992). [PMID: 12022200]

[EC created 1972 as EC, part transferred 1992 to EC, modified 1997]