EC 3.4.24.22 - Stromelysin 2

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IntEnz Enzyme Nomenclature
EC 3.4.24.22

Names

Accepted name:
stromelysin 2
Other names:
matrix metalloproteinase 10
proteoglycanase 2
transin 2
Systematic name:

Reaction

Cofactors

Comments:

In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030303
CAS Registry Number: 140610-48-6
UniProtKB/Swiss-Prot:

References

  1. Breathnach, R., Matrisian, L.M., Gesnel, M.-C. and Leroy, P.
    Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene.
    Nucleic Acids Res. 15: 1139-1151 (1987). [PMID: 3547333]
  2. Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R.
    The collagenase gene family in humans consists of at least four members.
    Biochem. J. 253: 187-192 (1988). [PMID: 2844164]
  3. Nicholson, R., Murphy, G. and Breathnach, R.
    Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.
    Biochemistry 28: 5195-5203 (1989). [PMID: 89352605]

[EC 3.4.24.22 created 1992]