EC - Astacin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Astacus proteinase
crayfish small-molecule proteinase
Systematic name:




A 22.6 kDa digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis. Type example of peptidase family M12. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008533
CAS Registry Number: 143179-21-9


  1. Krauhs, E., Dörsam, H., Little, M., Zwilling, R. and Ponstingl, H.
    A protease from Astacus fluviatilis as an aid in protein sequencing.
    Anal. Biochem. 119: 153-157 (1982). [PMID: 7041692]
  2. Titani, K., Torff, H.-J., Hormel, S., Kumar, S., Walsh, K.A., Rödl, J., Neurath, H. and Zwilling, R.
    Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis.
    Biochemistry 26: 222-226 (1987). [PMID: 3548817]
  3. Stöcker, W., Wolz, R.L., Zwilling, R., Strydom, D.J. and Auld, D.S.
    Astacus protease, a zinc metalloenzyme.
    Biochemistry 27: 5026-5032 (1988).
  4. Stöcker, W., Ng, M. and Auld, D.S.
    Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease.
    Biochemistry 29: 10418-10425 (1990). [PMID: 2261483]

[EC created 1972 as EC, transferred 1992 to EC]