EC - Procollagen C-endopeptidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
procollagen C-endopeptidase
Other names:
carboxyprocollagen peptidase
procollagen C-proteinase
procollagen C-terminal peptidase
procollagen C-terminal proteinase
procollagen carboxy-terminal proteinase
procollagen carboxypeptidase
procollagen peptidase
Systematic name:




A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004222
CAS Registry Number: 68651-95-6


  1. Hojima, Y., van der Rest, M. and Prockop, D.J.
    Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization.
    J. Biol. Chem. 260 : 15996-16003 (1985). [PMID: 3905801]
  2. Kessler, E. and Adar, R.
    Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein.
    Eur. J. Biochem. 186 : 115-121 (1989). [PMID: 2689170]

[EC created 1992]