EC 3.4.24.19 - Procollagen C-endopeptidase

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IntEnz Enzyme Nomenclature
EC 3.4.24.19

Names

Accepted name:
procollagen C-endopeptidase
Other names:
carboxyprocollagen peptidase
procollagen C-proteinase
procollagen C-terminal peptidase
procollagen C-terminal proteinase
procollagen carboxy-terminal proteinase
procollagen carboxypeptidase
procollagen peptidase
Systematic name:

Reaction

Cofactor

Comments:

A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004222
CAS Registry Number: 68651-95-6
UniProtKB/Swiss-Prot:

References

  1. Hojima, Y., van der Rest, M. and Prockop, D.J.
    Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization.
    J. Biol. Chem. 260 : 15996-16003 (1985). [PMID: 3905801]
  2. Kessler, E. and Adar, R.
    Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein.
    Eur. J. Biochem. 186 : 115-121 (1989). [PMID: 2689170]

[EC 3.4.24.19 created 1992]