EC 22.214.171.124 - Stromelysin 1
IntEnz Enzyme Nomenclature
collagenase activating protein
matrix metalloproteinase 3
- Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family).
Links to other databases
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.J. Biol. Chem. 260: 12367-12376 (1985). [PMID: 2995374]
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.J. Biol. Chem. 261: 14245-14255 (1986). [PMID: 3095317]
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.Ann. Rheum. Dis. 49: 469-479 (1990). [PMID: 2197998]
Matrix metalloproteinase. A review.Cell. Mol. Biol. 36: 131-153 (1990). [PMID: 2165861]
[EC 126.96.36.199 created 1990]