EC 3.4.24.17 - Stromelysin 1

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IntEnz Enzyme Nomenclature
EC 3.4.24.17

Names

Accepted name:
stromelysin 1
Other names:
MMP-3
collagen-activating protein
collagenase activating protein
matrix metalloproteinase 3
neutral proteoglycanase
procollagenase activator
proteoglycanase
stromelysin
transin
Systematic name:

Reaction

Cofactors

Comments:

An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004248
CAS Registry Number: 79955-99-0
UniProtKB/Swiss-Prot:

References

  1. Chin, J.R., Murphy, G. and Werb, Z.
    Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
    J. Biol. Chem. 260: 12367-12376 (1985). [PMID: 2995374]
  2. Okada, Y., Nagase, H. and Harris, E.D., Jr
    A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
    J. Biol. Chem. 261: 14245-14255 (1986). [PMID: 3095317]
  3. Docherty, A.J.P. and Murphy, G.
    The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
    Ann. Rheum. Dis. 49: 469-479 (1990). [PMID: 2197998]
  4. Emonard, H. and Grimaud, J.-A.
    Matrix metalloproteinase. A review.
    Cell. Mol. Biol. 36: 131-153 (1990). [PMID: 2165861]

[EC 3.4.24.17 created 1990]