EC - Neurolysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
endo-oligopeptidase B (proline-endopeptidase)
endopeptidase 24.16
neurotensin endopeptidase
Systematic name:




No absolute requirement for a prolyl bond: the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. In peptidase family M3 (thimet oligopeptidase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 149371-24-4
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Checler, F., Vincent, J.P. and Kitabgi, P.
    Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes.
    J. Biol. Chem. 261 : 11274-11281 (1986). [PMID: 3525564]
  2. Barelli, H., Vincent, J.-P. and Checler, F.
    Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum.
    Eur. J. Biochem. 175 : 481-489 (1988). [PMID: 3409880]
  3. Checler, F., Barelli, H. and Vincent, J.-P.
    Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies.
    Biochem. J. 257 : 549-554 (1989). [PMID: 2649078]

[EC created 1989]