EC - Procollagen N-endopeptidase

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IntEnz Enzyme Nomenclature


Accepted name:
procollagen N-endopeptidase
Other names:
aminoprocollagen peptidase
aminoterminal procollagen peptidase
procollagen N-terminal peptidase
procollagen N-terminal proteinase
procollagen aminopeptidase
procollagen aminoterminal protease
type I/II procollagen N-proteinase
type III procollagen
procollagen N-proteinase
Systematic name:




Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017074
CAS Registry Number: 68651-94-5


  1. Kohn, L.D., Iserky, C., Zupnik, J., Lenaers, A., Lee, G. and Lapiére, C.M.
    Calf tendon procollagen peptidase: its purification and endopeptidase mode of action.
    Proc. Natl. Acad. Sci. USA 71: 40-44 (1974). [PMID: 4204204]
  2. Hojima, Y., McKenzie, J., van der Rest, M. and Prockop, D.J.
    Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides.
    J. Biol. Chem. 264: 11336-11345 (1989). [PMID: 2500439]

[EC created 1984]