EC - IgA-specific metalloendopeptidase

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IntEnz Enzyme Nomenclature


Accepted name:
IgA-specific metalloendopeptidase
Other names:
IgA protease
IgA1 protease
IgA1 proteinase
IgA1-specific proteinase
immunoglobulin A1 proteinase
Systematic name:




A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of serine-type (see EC, IgA-specific serine endopeptidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 72231-73-3


  1. Kornfeld, S.J. and Plaut, A.G.
    Secretory immunity and the bacterial IgA proteases.
    Rev. Infect. Dis. 3: 521-534 (1981). [PMID: 6792682]
  2. Gilbert, J.V., Plaut, A.G. and Wright, A.
    Analysis of the immunoglobulin A protease gene of Streptococcus sanguis.
    Infect. Immun. 59: 7-17 (1991). [PMID: 1987065]
  3. Gilbert, J.V., Plaut, A.G., Fishman, Y. and Wright, A.
    Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli.
    Infect. Immun. 56: 1961-1966 (1988). [PMID: 3294181]

[EC created 1984]