EC 3.4.24.12 - Envelysin

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IntEnz Enzyme Nomenclature
EC 3.4.24.12

Names

Accepted name:
envelysin
Other names:
chorion-digesting proteinase
chorionase
chymostrypsin
hatching enzyme
sea urchin embryo hatching enzyme
sea-urchin-hatching proteinase
Systematic name:

Reaction

Cofactors

Comments:

A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 50812-13-0
UniProtKB/Swiss-Prot:

References

  1. Barrett, D. and Edwards, B.F.
    Hatching enzyme of the sea urchin Strongylocentrotus purpuratus.
    Methods Enzymol. 45: 354-373 (1976). [PMID: 1012003]
  2. Lepage, T. and Gache, C.
    Purification and characterization of the sea urchin embryo hatching enzyme.
    J. Biol. Chem. 264: 4787-4793 (1989). [PMID: 2925668]
  3. Lepage, T. and Gache, C.
    Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.
    EMBO J. 9: 3003-3012 (1990). [PMID: 2167841]
  4. Nomura, K., Tanaka, H., Kikkawa, Y., Yamaguchi, M. and Suzuki, N.
    The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family.
    Biochemistry 30: 6115-6123 (1991). [PMID: 1711895]

[EC 3.4.24.12 created 1978]