EC - Neprilysin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
CALLA (common acute lymphoblastic leukemia-associated) antigens
CALLA antigen
CALLA glycoprotein
CALLA glycoproteins
acute lymphoblastic leukemia antigen
common acute lymphoblastic leukemia antigen
common acute lymphoblastic leukemia-associated antigens
endopeptidase 24.11
enkephalinase [misleading]
kidney-brush-border neutral endopeptidase
kidney-brush-border neutral peptidase
kidney-brush-border neutral proteinase
membrane metalloendopeptidase
neutral endopeptidase
neutral endopeptidase 24.11
neutral metallendopeptidase
Systematic name:




A membrane-bound glycoprotein widely distributed in animal tissues. Inhibited by phosphoramidon and thiorphan. Common acute lymphoblastic leukemia antigen (CALLA). Type example of peptidase family M13.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004222
CAS Registry Number: 82707-54-8
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Matsas, R., Fulcher, I.S., Kenny, A.J. and Turner, A.J.
    Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
    Proc. Natl. Acad. Sci. USA 80 : 3111-3115 (1983). [PMID: 6190172]
  2. Malfroy, B., Schofield, P.R., Kuang, W.-J., Seeburg, P.H., Mason, A.J. Henzel, W.J.
    Molecular cloning and amino acid sequence of rat enkephalinase.
    Biochem. Biophys. Res. Commun. 144 : 59-66 (1987). [PMID: 3555489]
  3. Letarte, M., Vera, S., Tran, R., Addis, J.B.L., Onizuka, R.J., Quackenbush, E J., Jongneel, C.V. and McInnes, R.R.
    Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.
    J. Exp. Med. 168 : 1247-1253 (1988). [PMID: 2971756]
  4. Erdös, E.G. and Skidgel, R.A.
    Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones.
    FASEB J. 3 : 145-151 (1989). [PMID: 2521610]

[EC created 1978, modified 1989]