EC 3.4.24.1 - Atrolysin A

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IntEnz Enzyme Nomenclature
EC 3.4.24.1

Names

Accepted name:
atrolysin A
Other names:
Crotalus atrox α-proteinase
Crotalus atrox metalloendopeptidase a
Crotalus atrox proteinase
bothropasin
hemorrhagic toxin a
Crotalus atrox metalloproteinase
Systematic name:
-

Reaction

Cofactor

Comments:

A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic toxins in the venom of western diamondback rattlesnake. The 60 kDa hemorrhagic toxin 1 of Crotalus ruber ruber shows identical specificity [2]. In peptidase family M12 (astacin family). Related metalloendopeptidases from rattlesnake venoms are EC 3.4.24.41 (atrolysin B), EC 3.4.24.42 (atrolysin C), EC 3.4.24.43 (atroxase), EC 3.4.24.44 (atrolysin E), EC 3.4.24.45 (atrolysin F), EC 3.4.24.46 (adamalysin), EC 3.4.24.47 (horrilysin), and EC 3.4.24.48 (ruberlysin).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00129
Structural data: CSA , EC2PDB
CAS Registry Number: 37288-82-7
UniProtKB/Swiss-Prot:

References

  1. Bjarnason, J.B. and Tu, A.T.
    Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e.
    Biochemistry 17: 3395-3404 (1978). [PMID: 210790]
  2. Mori, N., Nikai, T., Sugihara, H. and Tu, A.T.
    Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom.
    Arch. Biochem. Biophys 253: 108-121 (1987). [PMID: 2949699]
  3. Bjarnason, J.B., Hamilton, D. and Fox, J.W.
    Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom.
    Biol. Chem. Hoppe-Seyler 369: 121-129 (1988). [PMID: 3060135]
  4. Bjarnason, J.B. and Fox, J.W.
    Hemorrhagic toxins from snake venoms.
    J. Toxicol. Toxin Rev. 7: 121-209 (1989).

[EC 3.4.24.1 created 1972, modified 1986]