EC - HycI peptidase

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IntEnz Enzyme Nomenclature


Accepted name:
HycI peptidase
Other names:
HycE processing protein
Systematic name:



The reaction requires nickel to be bound to the precursor of the large subunit of hydrogenase 3. The endopeptidase uses the metal in the large subunit of [NiFe]-hydrogenases as a recognition motif [1]. In peptidase family A31.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Theodoratou, E., Paschos, A., Magalon, A., Fritsche, E., Huber, R., Bock, A.
    Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation.
    Eur. J. Biochem. 267 : 1995-1999 (2000). [PMID: 10727938]
  2. Yang, F., Hu, W., Xu, H., Li, C., Xia, B., Jin, C.
    Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation.
    J. Biol. Chem. 282 : 3856-3863 (2007). [PMID: 17150961]

[EC created 2009]