EC - Cathepsin D

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IntEnz Enzyme Nomenclature


Accepted name:
cathepsin D
Systematic name:



Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family). Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004190
CAS Registry Number: 9025-26-7
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Barrett, A.J.
    Cathepsin D and other carboxyl proteinases.
    In: Barrett, A.J. (Ed.) Proteinases in Mammalian Cells and Tissues , North-Holland Publishing Co , Amsterdam , 1977 , 209-248
  2. Takahashi, T. and Tang, J.
    Cathepsin D from porcine and bovine spleen.
    Methods Enzymol. 80C : 565-581 (1981). [PMID: 7341918]
  3. Faust, P.L., Kornfeld, S. and Chirgwin, J.M.
    Cloning and sequence analysis of cDNA for human cathepsin D.
    Proc. Natl. Acad. Sci. USA 82 : 4910-4914 (1985). [PMID: 3927292]
  4. Conner, G.E.
    Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme.
    Biochem. J. 263 : 601-604 (1989). [PMID: 2512908]

[EC created 1965 as EC, transferred 1972 to EC, modified 1986]