EC 18.104.22.168 - Omptin
IntEnz Enzyme Nomenclature
gene ompT proteins
- Has a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1' position, which can also contain Lys, Gly or Val.
A product of the ompT gene of Escherichia coli, and associated with the outer membrane. Omptin shows a preference for cleavage between consecutive basic amino acids, but is capable of cleavage when P1' is a non-basic residue [5,7]. Belongs in peptidase peptidase family A26.
Links to other databases
Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12.Nucleic Acids Res. 16 : 1209 (1988). [PMID: 3278297]
Purification, characterization, and primary structure of Escherichia coli protease VII with specificity for paired basic residues: identity of protease VII and ompT.J. Bacteriol. 170 : 5625-5632 (1988). [PMID: 3056908]
Processing by OmpT of fusion proteins carrying the HlyA transport signal during secretion by the Escherichia coli hemolysin transport system.Mol. Gen. Genet. 233 : 42-48 (1992). [PMID: 1603076]
Omptin.In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes , 2nd ed. , Elsevier , London , 2004 , 212-216
Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.EMBO J. 20 : 5033-5039 (2001). [PMID: 11566868]
Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site.FEBS Lett. 505 : 426-430 (2001). [PMID: 11576541]
Substrate specificity of the Escherichia coli outer membrane protease OmpT.J. Bacteriol. 186 : 5919-5925 (2004). [PMID: 15317797]
[EC 22.214.171.124 created 1993 as EC 126.96.36.199, transferred 2006 to EC 188.8.131.52]