EC - Memapsin 2

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IntEnz Enzyme Nomenclature


Accepted name:
memapsin 2
Other names:
β-secretase [ambiguous]
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
β-site APP-cleaving enzyme 1
membrane-associated aspartic protease 2
β-site Alzheimer's amyloid precursor protein cleaving enzyme 1
Systematic name:



Suggested to be the major "β-secretase" responsible for the cleavage of the β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Turner, R.T., III, Koelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J.
    Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design.
    Biochemistry 40 : 10001-10006 (2001). [PMID: 11513577]
  2. Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J.
    Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3.
    Biochemistry 41 : 10963-10967 (2002). [PMID: 12206667]

[EC created 2003]