EC 126.96.36.199 - Memapsin 1
IntEnz Enzyme Nomenclature
β-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2)
Down region aspartic protease
β-site Alzheimer's amyloid precursor protein cleaving enzyme 2
membrane-associated aspartic protease 1
β-site APP-cleaving enzyme 2
- Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu┼Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
Can cleave β-amyloid precursor protein to form the amyloidogenic β-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.
Links to other databases
Specificity of memapsin 1 and its implications on the design of memapsin 2 (β-secretase) inhibitor selectivity.Biochemistry 41: 8742-8746 (2002). [PMID: 12093293]
[EC 188.8.131.52 created 2003]