EC 188.8.131.52 - Chymosin
IntEnz Enzyme Nomenclature
- Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105┼Met-Ala bond in κ-chain of casein.
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1 (pepsin A family).
Links to other databases
A review of prorennin and rennin.C. R. Trav. Lab. Carlsberg 35: 143-231 (1966). [PMID: 5330666]
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.Nucleic Acids Res. 10: 2177-2187 (1982). [PMID: 6283469]
Peptide substrates for chymosin (rennin). Interaction sites inκ-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.Biochem. J. 244: 553-558 (1987). [PMID: 3128264]
[EC 184.108.40.206 created 1961 as EC 220.127.116.11, transferred 1972 to EC 18.104.22.168, modified 1986]