EC - Chymosin

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IntEnz Enzyme Nomenclature


Accepted name:
Other name:
rennin (but this should be avoided since it leads to confusion with renin)
Systematic name:



Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1 (pepsin A family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030602
CAS Registry Number: 9001-98-3


  1. Foltmann, B.
    A review of prorennin and rennin.
    C. R. Trav. Lab. Carlsberg 35: 143-231 (1966). [PMID: 5330666]
  2. Harris, T.J.R., Lowe, P.A., Lyons, A., Thomas, P.G., Eaton, M.A.W., Millican, T.A., Patel, T.P., Bose, C.C., Carey, N.H. and Doel, M.T.
    Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
    Nucleic Acids Res. 10: 2177-2187 (1982). [PMID: 6283469]
  3. Visser, S., Slangen, C.J. and van Rooijen, P.J.
    Peptide substrates for chymosin (rennin). Interaction sites inκ-casein-related sequences located outside the (103-108)-hexapeptide region that fits into the enzyme's active-site cleft.
    Biochem. J. 244: 553-558 (1987). [PMID: 3128264]

[EC created 1961 as EC, transferred 1972 to EC, modified 1986]