EC 188.8.131.52 - Gastricsin
IntEnz Enzyme Nomenclature
pig parapepsin II
- More restricted specificity than pepsin A, but shows preferential cleavage at Tyr bonds. High activity on hemoglobin.
Formed from progastricsin, apparently in the gastric juice of most vertebrates. In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum. Seminal plasma contains a zymogen that is immunologically identical with progastricsin . In peptidase family A1 (pepsin A family). Formerly EC 184.108.40.206.
Links to other databases
The porcine pepsins and pepsinogens.Methods Enzymol. 19 : 316-336 (1970).
Gastricsin and pepsin.Methods Enzymol. 19 : 406-421 (1970).
Gastric proteinases - structure, function, evolution and mechanism of action.Essays Biochem. 17 : 52-84 (1981). [PMID: 6795036]
Human progastricsin - analysis of intermediates during activation into gastricsin and determination of the amino-acid sequence of the propart.Eur. J. Biochem. 128 : 63-70 (1982). [PMID: 6816595]
Purification and characterization of bovine gastricsin.Eur. J. Biochem. 122 : 31-39 (1982). [PMID: 6800788]
Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.Cell Tissue Res. 236 : 597-600 (1984). [PMID: 6432332]
Primary structure of human pepsinogen C gene.J. Biol. Chem. 263 : 1382-1385 (1988). [PMID: 3335549]
[EC 220.127.116.11 created 1965 as EC 18.104.22.168, transferred 1972 to EC 22.214.171.124, modified 1986]