EC 220.127.116.11 - HIV-1 retropepsin
IntEnz Enzyme Nomenclature
human immunodeficiency virus type 1 protease
- Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses . Type example of peptidase family A2.
Links to other databases
In: Kuo, L.C. and Shafer, J.A. (Eds.) Retroviral Proteases. Methods Enzymol. vol. 241 , 1994 , 1-431
Human immunodeficiency virus 1 retropepsin.In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes , Academic Press , London , 1998 , 919-928
[EC 18.104.22.168 created 1992, modified 2000]