EC - HIV-1 retropepsin

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IntEnz Enzyme Nomenclature


Accepted name:
HIV-1 retropepsin
Other names:
HIV aspartyl protease
HIV proteinase
HIV-1 protease
HIV-2 protease
gag protease
human immunodeficiency virus type 1 protease
Systematic name:



Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses [1]. Type example of peptidase family A2.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
CAS Registry Number: 144114-21-6
UniProtKB/Swiss-Prot: (51) [show] [UniProt]


  1. In: Kuo, L.C. and Shafer, J.A. (Eds.) Retroviral Proteases. Methods Enzymol. vol. 241 , 1994 , 1-431
  2. Dunn, B.M.
    Human immunodeficiency virus 1 retropepsin.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes , Academic Press , London , 1998 , 919-928

[EC created 1992, modified 2000]