EC - Renin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
angiotensin-forming enzyme
Systematic name:



Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family). Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00128
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004190
CAS Registry Number: 9015-94-5
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Inagami, T. and Murakami, K.
    Pure renin. Isolation from hog kidney and characterization.
    J. Biol. Chem. 252 : 2978-2983 (1977). [PMID: 16012]
  2. Slater, E.E.
    Methods Enzymol. 80 : 427-442 (1981). [PMID: 7043197]
  3. Inagami, T.
    Structure and function of renin.
    J. Hypertension Suppl. 7 : S3-S8 (1989). [PMID: 2666611]
  4. Sielecki, A.R., Hayakawa, K., Fujinaga, M., Murphy, M.E.P., Fraser, M., Muir, A.K., Carilli, C.T., Lewicki, J.A., Baxter, J.D. and James, M.N.G.
    Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution.
    Science 243 : 1346-1351 (1989). [PMID: 2493678]

[EC created 1961 as EC, transferred 1972 to EC, transferred 1981 to EC]