EC 220.127.116.11 - Nepenthesin
IntEnz Enzyme Nomenclature
Nepenthes aspartic proteinase
- Similar to pepsin, but also cleaves on either side of Asp and at Lys┼Arg.
From the insectivorous plants Nepenthes spp. (secretions) and Drosera peltata (ground-up leaves). Formerly EC 18.104.22.168. Aspartic endopeptidases are probably present in many other plants, including Lotus  (formerly EC 22.214.171.124) and sorghum  (formerly EC 126.96.36.199). In peptidase family A1 (pepsin A family).
Links to other databases
Acid protease in Nepenthes. II. Study on the specificty of nepenthesin.J. Biochem. (Tokyo) 66: 431-439 (1969). [PMID: 5354017]
Acid protease from germinated sorghum. 2. Substrate specificity with synthetic peptides and ribonuclease A.Eur. J. Biochem. 17: 4-12 (1970). [PMID: 5486576]
Studies on lotus seed protease. Part III. Some physicochemical and enzymic properties.Agric. Biol. Chem. 35: 1488-1494 (1971).
Digestive enzymes in insectivorous plants. III. Acid proteases in the genus Nepenthes and Drosera peltata.J. Biochem. (Tokyo) 72: 73-81 (1972). [PMID: 5069751]
Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin.J. Biochem. (Tokyo) 76: 897-899 (1974). [PMID: 4436292]
Digestive enzymes secreted by the carnivorous plant Nepenthes macferlani L.Planta 119: 39-46 (1974).
[EC 188.8.131.52 created 1972 as EC 184.108.40.206, transferred 1978 to EC 220.127.116.11, modified 1981]