EC - Nepenthesin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
Nepenthes acid proteinase
Nepenthes aspartic proteinase
aspartyl endopeptidase
Systematic name:



From the insectivorous plants Nepenthes spp. (secretions) and Drosera peltata (ground-up leaves). Formerly EC Aspartic endopeptidases are probably present in many other plants, including Lotus [3] (formerly EC and sorghum [2] (formerly EC In peptidase family A1 (pepsin A family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 9073-80-7


  1. Amagase, S., Nakayama, S. and Tsugita, A.
    Acid protease in Nepenthes. II. Study on the specificty of nepenthesin.
    J. Biochem. (Tokyo) 66: 431-439 (1969). [PMID: 5354017]
  2. Garg, G.K. and Virupaksha, T.K.
    Acid protease from germinated sorghum. 2. Substrate specificity with synthetic peptides and ribonuclease A.
    Eur. J. Biochem. 17: 4-12 (1970). [PMID: 5486576]
  3. Shinano, S. and Fukushima, K.
    Studies on lotus seed protease. Part III. Some physicochemical and enzymic properties.
    Agric. Biol. Chem. 35: 1488-1494 (1971).
  4. Amagase, S.
    Digestive enzymes in insectivorous plants. III. Acid proteases in the genus Nepenthes and Drosera peltata.
    J. Biochem. (Tokyo) 72: 73-81 (1972). [PMID: 5069751]
  5. Takahashi, K., Chang, W-J. and Ko, J-S.
    Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin.
    J. Biochem. (Tokyo) 76: 897-899 (1974). [PMID: 4436292]
  6. Tökés, Z.A., Woon, W.C. and Chambers, S.M.
    Digestive enzymes secreted by the carnivorous plant Nepenthes macferlani L.
    Planta 119: 39-46 (1974).

[EC created 1972 as EC, transferred 1978 to EC, modified 1981]