EC - SARS coronavirus main proteinase

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IntEnz Enzyme Nomenclature


Accepted name:
SARS coronavirus main proteinase
Other names:
3C-like protease
coronavirus 3C-like protease
SARS 3C-like protease
SARS coronavirus 3CL protease
SARS coronavirus main peptidase
SARS coronavirus main protease
SARS-CoV 3CLpro enzyme
SARS-CoV main protease
severe acute respiratory syndrome coronavirus main protease
Systematic name:



SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. In peptidase family C30.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (42) [show] [UniProt]


  1. Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S.
    Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
    Biochemistry 46 : 8744-8752 (2007). [PMID: 17605471]
  2. Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J., Lai, L.
    Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase.
    J. Biol. Chem. 279 : 1637-1642 (2004). [PMID: 14561748]
  3. Akaji, K., Konno, H., Onozuka, M., Makino, A., Saito, H., Nosaka, K.
    Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant.
    Bioorg. Med. Chem. 16 : 9400-9408 (2008). [PMID: 18845442]

[EC created 2009]