EC 3.4.22.69 - SARS coronavirus main proteinase

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IntEnz Enzyme Nomenclature
EC 3.4.22.69

Names

Accepted name:
SARS coronavirus main proteinase
Other names:
3cLpro
3C-like protease
coronavirus 3C-like protease
Mpro
SARS 3C-like protease
SARS coronavirus 3CL protease
SARS coronavirus main peptidase
SARS coronavirus main protease
SARS-CoV 3CLpro enzyme
SARS-CoV main protease
SARS-CoV Mpro
severe acute respiratory syndrome coronavirus main protease
Systematic name:
-

Reaction

Comments:

SARS coronavirus main protease is the key enzyme in SARS coronavirus replicase polyprotein processing. In peptidase family C30.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (42) [show] [UniProt]

References

  1. Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S.
    Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
    Biochemistry 46 : 8744-8752 (2007). [PMID: 17605471]
  2. Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J., Lai, L.
    Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase.
    J. Biol. Chem. 279 : 1637-1642 (2004). [PMID: 14561748]
  3. Akaji, K., Konno, H., Onozuka, M., Makino, A., Saito, H., Nosaka, K.
    Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant.
    Bioorg. Med. Chem. 16 : 9400-9408 (2008). [PMID: 18845442]

[EC 3.4.22.69 created 2009]