EC 3.4.22.67 - Zingipain

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IntEnz Enzyme Nomenclature
EC 3.4.22.67

Names

Accepted name:
zingipain
Other names:
ginger protease
GP-I
GP-II
ginger protease II (Zingiber officinale)
zingibain
Systematic name:
-

Reaction

Comments:

This enzyme is found in ginger (Zingiber officinale) rhizome and is a member of the papain family. GP-II contains two glycosylation sites. The enzyme is inhibited by some divalent metal ions, such as Hg2+, Cu2+, Cd2+ and Zn2+ [2]. Belongs in peptidase family C1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Choi, K.H. and Laursen, R.A.
    Amino-acid sequence and glycan structures of cysteine proteases with proline specificity from ginger rhizome Zingiber officinale.
    Eur. J. Biochem. 267: 1516-1526 (2000). [PMID: 10691991]
  2. Ohtsuki, K., Taguchi, K., Sato, K. and Kawabata, M.
    Purification of ginger proteases by DEAE-Sepharose and isoelectric focusing.
    Biochim. Biophys. Acta 1243: 181-184 (1995). [PMID: 7873561]
  3. Choi, K.H., Laursen, R.A. and Allen, K.N.
    The 2.1 Å structure of a cysteine protease with proline specificity from ginger rhizome, Zingiber officinale.
    Biochemistry 38: 11624-11633 (1999). [PMID: 10512617]

[EC 3.4.22.67 created 2007]