EC - Caspase-11

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IntEnz Enzyme Nomenclature


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This murine enzyme is part of the family of inflammatory-caspases, which also includes caspase-1 (EC, caspase-4 (EC and caspase-5 (EC in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide [1]. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, but it also activates caspase-3 (EC, which leads to cellular apoptosis under pathological conditions [1,2]. Belongs in peptidase family C14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00864
Structural data: CSA , EC2PDB


  1. Kang, S.-J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A. and Yuan, J.
    Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions.
    J. Cell Biol. 149: 613-622 (2000). [PMID: 10791975]
  2. Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.-S. and Suk, K.
    Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway.
    FEBS Lett. 507: 157-162 (2001). [PMID: 11684090]
  3. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E. and Yuan, J.
    Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.
    Cell 92: 501-509 (1998). [PMID: 9491891]
  4. Endo, M., Mori, M., Akira, S. and Gotoh, T.
    C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation.
    J. Immunol. 176: 6245-6253 (2006). [PMID: 16670335]
  5. Chang, H.Y. and Yang, X.
    Proteases for cell suicide: functions and regulation of caspases.
    Microbiol. Mol. Biol. Rev. 64: 821-846 (2000). [PMID: 11104820]

[EC created 2007]