EC - Chymopapain

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
chymopapain A
chymopapain B
chymopapain S
Systematic name:



The major endopeptidase of papaya (Carica papaya) latex. It has multiple chromatographic forms. In peptidase family C1 (papain family). Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 9001-09-6


  1. Brocklehurst, K., Willenbrock, F. and Salih, E.
    Cysteine proteinases.
    New Comprehensive Biochemistry 16: 39-158 (1987).
  2. Jacquet, A., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G.
    The thiol proteinases from the latex of Carica papaya L. III. The primary structure of chymopapain.
    Biol. Chem. Hoppe-Seyler 370: 425-434 (1989). [PMID: 2500950]
  3. Buttle, D.J., Dando, P.M., Coe, P.F., Sharp, S.L., Shepherd, S.T. and Barrett, A.J.
    The preparation of fully active chymopapain free of contaminating proteinases.
    Biol. Chem. Hoppe-Seyler 371: 1083-1088 (1990). [PMID: 2085414]

[EC created 1961 as EC, transferred 1972 to EC]