EC - Caspase-5

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
ICH-3 protease
transcript Y
Systematic name:



This enzyme is part of the family of inflammatory-caspases, which also includes caspase-1 (EC and caspase-4 (EC in humans and caspase-11 (EC, caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1β [1,4]. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. Unlike caspase-4, this enzyme can be induced by lipopolysaccharide [3]. Belongs in peptidase family C14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00864
Structural data: CSA , EC2PDB


  1. Faucheu, C., Blanchet, A.-M., Collard-Dutilleul, V., Lalanne, J.L. and Diu-Hercend, A.
    Identification of a cysteine protease closely related to interleukin-1β-converting enzyme.
    Eur. J. Biochem. 236: 207-213 (1996). [PMID: 8617266]
  2. Kamada, S., Funahashi, Y. and Tsujimoto, Y.
    Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
    Cell Death Differ. 4: 473-478 (1997). [PMID: 16465268]
  3. Lin, X.Y., Choi, M.S.K. and Porter, A.G.
    Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ.
    J. Biol. Chem. 275: 39920-39926 (2000). [PMID: 10986288]
  4. Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.-M., Miossec, C. and Diu-Hercend, A.
    Enzymatic activity of two caspases related to interleukin-1β-converting enzyme.
    Eur. J. Biochem. 253: 76-83 (1998). [PMID: 9578463]
  5. Martinon, F. and Tschopp, J.
    Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
    Cell 117: 561-574 (2004). [PMID: 15163405]
  6. Chang, H.Y. and Yang, X.
    Proteases for cell suicide: functions and regulation of caspases.
    Microbiol. Mol. Biol. Rev. 64: 821-846 (2000). [PMID: 11104820]

[EC created 2007]