EC - Caspase-4

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
Other names:
transcript X
TX protease
caspase 4
Systematic name:



This enzyme is part of the family of inflammatory-caspases, which also includes caspase-1 (EC and caspase-5 (EC in humans and caspase-11 (EC, caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [3,5,6]. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1β [1,4]. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17) [3]. The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly [4]. Belongs in peptidase family C14.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00864
Structural data: CSA , EC2PDB


  1. Faucheu, C., Diu, A., Chan, A.W.E., Blanchet, A.-M., Miossec, C., Hervé, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., Lippke, J.A, Rocher, C., Su, M.S.-S., Livingston, D.J., Hercend, T. and Lalanne, J.-L.
    A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells.
    EMBO J. 14: 1914-1922 (1995). [PMID: 7743998]
  2. Kamens, J., Paskind, M., Hugunin, M., Talanian, R.V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C.G., Li, P., Mankovich, J.A., Terranova, M. and Ghayur, T.
    Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cysteine proteases.
    J. Biol. Chem. 270: 15250-15256 (1995). [PMID: 7797510]
  3. Kamada, S., Funahashi, Y., Tsujimoto, Y.
    Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.
    Cell Death Differ. 4: 473-478 (1997). [PMID: 16465268]
  4. Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.-M., Miossec, C., Diu-Hercend, A.
    Enzymatic activity of two caspases related to interleukin-1β-converting enzyme.
    Eur. J. Biochem. 253: 76-83 (1998). [PMID: 9578463]
  5. Martinon, F. and Tschopp, J.
    Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
    Cell 117: 561-574 (2004). [PMID: 15163405]
  6. Chang, H.Y and, Yang, X.
    Proteases for cell suicide: functions and regulation of caspases.
    Microbiol. Mol. Biol. Rev. 64: 821-846 (2000). [PMID: 11104820]

[EC created 2007]