EC - Calpain-2

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
calcium-activated neutral protease II
Systematic name:




Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC, calpain-1.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 78990-62-2
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K. and Bode, W.
    The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
    Proc. Natl. Acad. Sci. USA 97: 588-592 (2000). [PMID: 10639123]
  2. Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S.
    Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain.
    Biochem. J. 367: 263-269 (2002). [PMID: 12014988]

[EC created 1981 as EC, transferred 2003 to EC]