EC 22.214.171.124 - Calpain-2
IntEnz Enzyme Nomenclature
- Broad endopeptidase specificity.
Type example of peptidase family C2. Requires Ca2+ at millimolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 126.96.36.199, calpain-1.
Links to other databases
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.Proc. Natl. Acad. Sci. USA 97: 588-592 (2000). [PMID: 10639123]
Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain.Biochem. J. 367: 263-269 (2002). [PMID: 12014988]
[EC 188.8.131.52 created 1981 as EC 184.108.40.206, transferred 2003 to EC 220.127.116.11]