EC 220.127.116.11 - Calpain-1
IntEnz Enzyme Nomenclature
calcium-activated neutral protease I
- Broad endopeptidase specificity.
In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 18.104.22.168, calpain-2.
Links to other databases
Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain.Biochem. J. 367: 263-269 (2002). [PMID: 12014988]
[EC 22.214.171.124 created 1981 as EC 126.96.36.199, transferred 2003 to EC 188.8.131.52]