EC 126.96.36.199 - Cathepsin O
IntEnz Enzyme Nomenclature
- The recombinant human enzyme hydrolyses synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.
Cathepsin O is a lysosomal cysteine peptidase of family C1 (papain family). The recombinant human enzyme is catalytically active at pH 6.0 and is inhibited by compound E-64. Cathepsin O is ubiquitously expressed in human tissues and the human gene locus is 4q31-32.
Links to other databases
Genomic structure and chromosomal localization of a human cathepsin O gene (CTSO).Genomics 53: 231-234 (1998). [PMID: 9790772]
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.J. Biol. Chem. 269: 27136-27142 (1994). [PMID: 7929457]
[EC 188.8.131.52 created 2000]