EC - Caricain

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
chymopapain S
papaya peptidase A
papaya peptidase II
papaya proteinase 3
papaya proteinase Ω
papaya proteinase A
papaya proteinase III
proteinase ω
Systematic name:



From papaya plant, Carica papaya. In peptidase family C1 (papain family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00126
Structural data: CSA , EC2PDB
CAS Registry Number: 39307-22-7


  1. Schack, P.
    Fractionation of proteolytic enzymes of dried papaya latex. Isolation and preliminary characterization of a new proteolytic enzyme.
    C. R. Trav. Carlesberg 36: 67-83 (1967). [PMID: 6043136]
  2. Robinson, G.W.
    Isolation and characterization of papaya peptidase A from commercial chymopapain.
    Biochemistry 16: 3695-3700 (1975). [PMID: 240390]
  3. Polgár, L.
    Problems of classification of papaya latex proteinases.
    Biochem. J. 221: 555-556 (1984). [PMID: 6383350]
  4. Brocklehurst, K., Salih, E., McKee, R. and Smith, H.
    Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase Ω.
    Biochem. J. 228: 525-527 (1985). [PMID: 4015629]
  5. Zucker, S., Buttle, D.J., Nicklin, M.J.H. and Barrett, A.J.
    Proteolytic activities of papain, chymopapain and papaya proteinase III.
    Biochim. Biophys. Acta 828: 196-204 (1985). [PMID: 3919769]
  6. Dubois, T., Kleinschmidt, T., Schnek, A.G., Looze, Y. and Braunitzer, G.
    The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase Ω.
    Biol. Chem. Hoppe-Seyler 369: 741-754 (1988). [PMID: 3063283]

[EC created 1992]