EC - Picornain 2A

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
picornain 2A
Other names:
2A protease
2A proteinase
Y-G proteinase 2A
picornaviral 2A proteinase
picornavirus endopeptidase 2A
poliovirus protease 2A
poliovirus protease 2Apro
poliovirus proteinase 2A
protease 2A
proteinase 2Apro
rhinovirus protease 2A
Systematic name:



From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 103406-62-8
UniProtKB/Swiss-Prot: (46) [show] [UniProt]


  1. Bazan, J.F. and Fletterick, R.J.
    Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
    Proc. Natl. Acad. Sci. USA 85 : 7872-7876 (1988). [PMID: 3186696]
  2. König, H. and Rosenwirth, B.
    Purification and partial characterization of poliovirus protease 2A by means of a functional assay.
    J. Virol. 62 : 1243-1250 (1988). [PMID: 2831385]
  3. Kräusslich, H.-G. and Wimmer, E.
    Viral proteinases.
    Annu. Rev. Biochem. 57 : 701-754 (1988). [PMID: 3052288]

[EC created 1992]