EC - Picornain 3C

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IntEnz Enzyme Nomenclature


Accepted name:
picornain 3C
Other names:
3C protease
3C proteinase
coxsackievirus 3C proteinase
cysteine proteinase 3C
foot-and-mouth protease 3C
foot-and-mouth-disease virus proteinase 3C
hepatitis A virus 3C proteinase
picornavirus endopeptidase 3C
poliovirus protease 3C
poliovirus proteinase 3C
protease 3C
rhinovirus protease 3C
rhinovirus proteinase 3C
tomato ringspot nepovirus 3C-related protease
Systematic name:



From entero-, rhino-, aphto- and cardioviruses. Larger than the homologous virus picornain 2A. Type example of peptidase family C3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004197
CAS Registry Number: 97162-88-4
UniProtKB/Swiss-Prot: (93) [show] [UniProt]


  1. Ivanoff, L.A., Towatari, T., Ray, J., Korant, B.D. and Petteway, S.R.
    Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli.
    Proc. Natl. Acad. Sci. USA 83 : 5392-5396 (1986). [PMID: 3016701]
  2. Bazan, J.F. and Fletterick, R.J.
    Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
    Proc. Natl. Acad. Sci. USA 85 : 7872-7876 (1988). [PMID: 3186696]
  3. Kräusslich, H.-G. and Wimmer, E.
    Viral proteinases.
    Annu. Rev. Biochem. 57 : 701-754 (1988). [PMID: 3052288]
  4. Nicklin, M.J.H., Harris, K.S., Pallai, P.V. and Wimmer, E.
    Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.
    J. Virol. 62 : 4586-4593 (1988). [PMID: 2846872]

[EC created 1992]