EC - Assemblin

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IntEnz Enzyme Nomenclature


Accepted name:
Systematic name:



Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. Inhibited by diisopropyl fluorophosphate. Type example of peptidase family S21. Catalytic residues are His, Ser, His, a combination not known for any other peptidase, and the protein fold also is unique. Known from herpes viruses of several types, cytomegalovirus, Epstein-Barr virus and human herpesvirus 3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 139691-88-6
UniProtKB/Swiss-Prot: (24) [show] [UniProt]


  1. Chen, P., Tsuge, H., Almassy, R.J., Gribskov, C.L., Katoh, S., Vanderpool, D.L., Margosiak, S.A., Pinko, C., Matthews, D.A. and Kan, C.C.
    Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad.
    Cell 86: 477-483 (1996). [PMID: 8797829]
  2. Darke, P.L.
    Herpesvirus assemblin.
    In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.) Handbook of Proteolytic Enzymes, Academic Press, London, 1998, 470-472

[EC created 2000]