EC 18.104.22.168 - Proprotein convertase 2
IntEnz Enzyme Nomenclature
neuroendocrine convertase 2
- Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg┼ bonds.
A Ca2+-dependent enzyme, maximally active at about pH 5.5. Specificity is broader than that of prohormone convertase 1. Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proglucagon, proinsulin and proluteinizing-hormone-releasing-hormone. Does not hydrolyse prorenin or prosomatostatin, however. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 1. In peptidase family S8 (subtilisin family).
Links to other databases
cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.DNA Cell Biol. 9: 415-424 (1990). [PMID: 2169760]
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.J. Biol. Chem. 265: 2997-3000 (1990). [PMID: 2154467]
Proglucagon is processed to glucagon by prohormone convertase PC2 in αTC1-6 cells.Proc. Natl. Acad. Sci. USA 91: 3242-3246 (1994). [PMID: 8159732]
Pro-protein convertases of the subtilisin/kexin family.Methods Enzymol. 244: 175-188 (1994). [PMID: 7845206]
[EC 22.214.171.124 created 1996]