EC - Proprotein convertase 1

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IntEnz Enzyme Nomenclature


Accepted name:
proprotein convertase 1
Other names:
neuroendocrine convertase 1
prohormone convertase 3
prohormone convertase I
Systematic name:



A Ca2+-dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not hydrolyse proluteinizing-hormone-releasing-hormone. Unusually, processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly acting co-operatively with prohormone convertase 2. In peptidase family S8 (subtilisin family).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004285
CAS Registry Number: 99676-46-7


  1. Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. and Chrétien, M.
    cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
    DNA Cell Biol. 9: 415-424 (1990). [PMID: 2169760]
  2. Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J. and Steiner, D.F.
    Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
    Proc. Natl. Acad. Sci. USA 88: 340-344 (1991). [PMID: 1988934]
  3. Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J.
    The new enzymology of precursor processing endoproteases.
    J. Biol. Chem. 267: 23435-23438 (1992). [PMID: 1429684]
  4. Seidah, N.G. and Chrétien, M.
    Pro-protein convertases of the subtilisin/kexin family.
    Methods Enzymol. 244: 175-188 (1994). [PMID: 7845206]
  5. Jean, F., Basak, A., Dimaio, J., Seidah, N.G. and Lazure, C.
    An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor.
    Biochem. J. 307: 689-695 (1995). [PMID: 7741698]

[EC created 1996]