EC - Glutamyl endopeptidase II

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IntEnz Enzyme Nomenclature


Accepted name:
glutamyl endopeptidase II
Other name:
Systematic name:



From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18→Glu]-modified turkey ovomucoid third domain.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
CAS Registry Number: 137010-42-5


  1. Yoshida, N., Tsuruyama, S., Nagata, K., Hirayama, K., Noda, K. and Makisumi, S.
    Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase).
    J. Biochem. (Tokyo) 104: 451-456 (1988). [PMID: 3149277]
  2. Komiyama, T., Bigler, T.L., Yoshida, N., Noda, K. and Laskowski, M., Jr.
    Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus Proteinase (GluSGP).
    J. Biol. Chem. 266: 10727-10730 (1991). [PMID: 1674942]
  3. Nagata, K., Yoshida, N., Ogata, F., Araki, M. and Noda, K.
    Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8.
    J. Biochem. (Tokyo) 110: 859-862 (1991). [PMID: 1794975]
  4. Svendsen, I., Jensen, M.R. and Breddam, K.
    The primary structure of the glutamic acid-specific protease of Streptomyces griseus.
    FEBS Lett. 292: 165-167 (1991). [PMID: 1959600]
  5. Breddam, K. and Meldal, M.
    Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching.
    Eur. J. Biochem. 206: 103-107 (1992). [PMID: 1587264]

[EC created 1993]