EC - Furin

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
dibasic processing enzyme
paired basic amino acid cleaving enzyme
paired basic amino acid converting enzyme
prohormone convertase
proprotein convertase
serine proteinase PACE
Systematic name:



One of a group of peptidases in peptidase family S8 (subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00125
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004252
CAS Registry Number: 141760-45-4
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. van de Ven, W.J.M., Voorberg, J., Fontijn, R., Pannekoek, H., van den Ouweland, A.M.W., van Duijnhoven, H.L.P., Roebroek, A.J.M. and Siezen, R.J.
    Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.
    Mol. Biol. Rep. 14 : 265-275 (1990). [PMID: 2094803]
  2. van de Ven, W.J.M., Creemers, J.W.M. and Roebroek, A.J.M.
    Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway.
    Enzyme 45 : 257-270 (1991). [PMID: 1843280]
  3. Hatsuzawa, K., Murakami, K. and Nakayama, K.
    Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.
    J. Biochem. (Tokyo) 111 : 296-301 (1992). [PMID: 1587790]
  4. Seidah, N.G. and Chrétien, M.
    Proprotein and prohormone convertases of the subtilisin family: recent developments and future perspectives.
    Trends Endocrinol. Metab. 3 : 133-140 (1992).
  5. Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J.
    The new enzymology of precursor processing endoproteases.
    J. Biol. Chem. 267 : 23435-23438 (1992). [PMID: 1429684]

[EC created 1993]