EC - U-plasminogen activator

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IntEnz Enzyme Nomenclature


Accepted name:
u-plasminogen activator
Other names:
cellular plasminogen activator
double-chain urokinase-type plasminogen activator
two-chain urokinase-type plasminogen activator
urinary esterase A
urinary plasminogen activator
urokinase plasminogen activator
urokinase-type plasminogen activator
Systematic name:



Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC, and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC and EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008243
CAS Registry Number: 9039-53-6
UniProtKB/Swiss-Prot: (10) [show] [UniProt]


  1. Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L.
    Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
    Methods Enzymol. 80C : 341-361 (1981). [PMID: 6210826]
  2. Loskutoff, D.J. and Schleef, R.R.
    Plasminogen activators and their inhibitors.
    Methods Enzymol. 163 : 293-302 (1988). [PMID: 3148826]
  3. Saksela, O. and Rifkin, D.B.
    Cell-associated plasminogen activation: regulation and physiological functions.
    Annu. Rev. Cell Biol. 4 : 93-126 (1988). [PMID: 3143380]
  4. Collen, D., Lijnen, H.R. and Verstraete, M.
    The fibrinolytic system and its disorders.
    In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.) Blood: Principles and Practice of Hematology , 2nd ed. , J.B. Lippincott Company , Philadelphia , 1990
  5. Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D.
    Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Ala) and plasmin-resistant scu-PA (Lys158→Glu).
    J. Biol. Chem. 265 : 5232-5236 (1990). [PMID: 1969415]

[EC created 1972 as EC, transferred 1978 as EC, part transferred 1992 to EC]