EC 3.4.21.70 - Pancreatic endopeptidase E

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IntEnz Enzyme Nomenclature
EC 3.4.21.70

Names

Accepted name:
pancreatic endopeptidase E
Other names:
CBPP
cholesterol-binding pancreatic proteinase
cholesterol-binding proteinase
cholesterol-binding serine proteinase
pancreas E proteinase
pancreatic protease E
pancreatic proteinase E
proteinase E
Systematic name:

Reaction

Comments:

A peptidase of family S1 (trypsin family) from pancreatic juice. Unlike elastases, has an acidic pI. Binds cholesterol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
CAS Registry Number: 68073-27-8
UniProtKB/Swiss-Prot:

References

  1. Mallory, P.A. and Travis, J.
    Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E, resembling elastase.
    Biochemistry 14: 722-729 (1975). [PMID: 234742]
  2. Shen, W., Fletcher, T.S. and Largman, C.
    Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA.
    Biochemistry 26: 3447-3452 (1987). [PMID: 3477287]

[EC 3.4.21.70 created 1992]